Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00096272" target="_blank" >RIV/00216224:14110/17:00096272 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.canlet.2016.09.023" target="_blank" >http://dx.doi.org/10.1016/j.canlet.2016.09.023</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.canlet.2016.09.023" target="_blank" >10.1016/j.canlet.2016.09.023</a>

Result language

angličtina

Original language name

Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition

Original language description

A significant part of current research studies utilizes various cellular models which imply specific antibiotics-containing media as well as antibiotics used for clonal selection or promoter de/activation. With the great success of developing such tools, mitochondria, once originated from bacteria, can be effectively targeted by antibiotics. For that reason, some studies propose antibiotics-targeting of mitochondria as part of anticancer therapy. Here, we have focused on the effects of various classes of antibiotics on mitochondria in cancer and non-cancer cells and demonlow mitochondrial membrane potential, reduced ATP production, altered morphology and lowered respiration rate which altogether suggested mitochondrial dysfunction (MDF). This was in parallel with increased level of reactive oxygen species (ROS) and decreased activity of mitochondria( respiration complexes. However, both survival and repopulation capacity of cancer cells was not significantly affected by the antibiotics, perhaps due to a glycolytic shift or activated autophagy. In turn, simultaneous inhibition of autophagy and treatment with antibiotics largely reduced tumorigenic properties of cancer cells suggesting potential strategy for anticancer therapy. (C) 2016 Published by Elsevier Ireland Ltd.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer letters

ISSN

0304-3835

e-ISSN

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Volume of the periodical

384

Issue of the periodical within the volume

JAN 1 2017

Country of publishing house

IE - IRELAND

Number of pages

10

Pages from-to

60-69

UT code for WoS article

000389109700007

EID of the result in the Scopus database

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