Interrogating open issues in cancer precision medicine with patient-derived xenografts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00096873" target="_blank" >RIV/00216224:14110/17:00096873 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/nrc.2016.140" target="_blank" >http://dx.doi.org/10.1038/nrc.2016.140</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/nrc.2016.140" target="_blank" >10.1038/nrc.2016.140</a>
Alternative languages
Result language
angličtina
Original language name
Interrogating open issues in cancer precision medicine with patient-derived xenografts
Original language description
Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective ofEurOPDX, an international initiative devoted to PDX-based research.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
NATURE REVIEWS CANCER
ISSN
1474-175X
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
254-268
UT code for WoS article
000397089500010
EID of the result in the Scopus database
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