Metronomic therapy has low toxicity and is as effective as current standard treatment for recurrent high-risk neuroblastoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00102137" target="_blank" >RIV/00216224:14110/17:00102137 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/08880018.2017.1373314" target="_blank" >http://dx.doi.org/10.1080/08880018.2017.1373314</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/08880018.2017.1373314" target="_blank" >10.1080/08880018.2017.1373314</a>
Alternative languages
Result language
angličtina
Original language name
Metronomic therapy has low toxicity and is as effective as current standard treatment for recurrent high-risk neuroblastoma
Original language description
The metronomic therapy concept uses low doses of continuously applied chemotherapeutic, anti-angiogenetic, and immunomodulating drugs. Twenty patients with recurrent and 3 with refractory high-risk neuroblastoma were treated by the metronomic concept using celecoxib, cyclophosphamide, vinblastine, and etoposide for up to 24 months. The outcome was compared to 274 matched patients with a first recurrence from stage 4 neuroblastoma using the variables time from diagnosis to first recurrence, number of organs involved, and MYCN amplification. All were treated with dose-intensive conventional chemotherapy. The study patients experienced 1-3 recurrences and had 1-3 sites involved (osteomedullary, primary tumor, central nervous system, lymph nodes, liver, lungs) before the metronomic therapy started. Two patients in complete remission and three with active refractory disease following recurrence treatment were excluded from the outcome analysis. The curves for secondary event-free and overall survival demonstrated no significant differences.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pediatric Hematology and Oncology
ISSN
0888-0018
e-ISSN
1521-0669
Volume of the periodical
34
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
308-319
UT code for WoS article
000419983600006
EID of the result in the Scopus database
2-s2.0-85034232887