Bejel in Cuba: molecular identification of Treponema pallidum subsp endemicum in patients diagnosed with venereal syphilis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00101381" target="_blank" >RIV/00216224:14110/18:00101381 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.cmi.2018.02.006" target="_blank" >http://dx.doi.org/10.1016/j.cmi.2018.02.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cmi.2018.02.006" target="_blank" >10.1016/j.cmi.2018.02.006</a>

Result language

angličtina

Original language name

Bejel in Cuba: molecular identification of Treponema pallidum subsp endemicum in patients diagnosed with venereal syphilis

Original language description

Objectives: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. Methods: We performed sequencing-based molecular typing on 92 samples from Cuban individuals diagnosed with syphilis. Moreover, to differentiate T. pallidum subspecies, multi-locus sequence analysis (MLSA) was designed and was applied to suspicious samples. Results: Nine samples, from six patients, had a nucleotide sequence similarity (at all typing loci) to the Bosnia A genome, which is the infectious agent of bejel. Additionally, MLSA clearly supported a TEN classification for the treponemal samples. Clinical and epidemiological data from the six patients also suggested sexual transmission of bejel as well as the endemicity of this rare treponematosis in Cuba. Conclusions: Molecular identification of Treponema pallidum subsp. endemicum, the agent of bejel, in Cuban patients diagnosed with syphilis indicates the clear limitations of a diagnosis based exclusively on serology, geographical occurrence, clinical symptoms and anamnestic data. This finding has important implications for Global Public Health Systems, including paradigm changes regarding the location of endemic outbreaks, clinical aspects and transmission of this neglected disease. (C) 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30303 - Infectious Diseases

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Microbiology and Infection

ISSN

1198-743X

e-ISSN

1469-0691

Volume of the periodical

24

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

1-5

UT code for WoS article

000448188200019

EID of the result in the Scopus database

2-s2.0-85044616585