Genetics of human and animal uncultivable treponemal pathogens
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00101771" target="_blank" >RIV/00216224:14110/18:00101771 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.meegid.2018.03.015" target="_blank" >http://dx.doi.org/10.1016/j.meegid.2018.03.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.meegid.2018.03.015" target="_blank" >10.1016/j.meegid.2018.03.015</a>
Alternative languages
Result language
angličtina
Original language name
Genetics of human and animal uncultivable treponemal pathogens
Original language description
Treponema pallidum is an uncultivable bacterium and the causative agent of syphilis (subsp. pallidum [TPA]), human yaws (subsp. pertenue [TPE]), and bejel (subsp. endemicum). Several species of nonhuman primates in Africa are infected by treponemes genetically undistinguishable from known human TPE strains. Besides Treponema pallidum, the equally uncultivable Treponema carateum causes pinta in humans. In lagomorphs, Treponema paraluisleporidarum ecovar Cuniculus and ecovar Lepus are the causative agents of rabbit and hare syphilis, respectively. All uncultivable pathogenic treponemes harbor a relatively small chromosome (1.1334-1.1405 Mbp) and show gene synteny with minimal genetic differences (> 98% identity at the DNA level) between subspecies and species. While uncultivable pathogenic treponemes contain a highly conserved core genome, there are a number of highly variable and/or recombinant chromosomal loci. This is also reflected in the occurrence of intrastrain heterogeneity (genetic diversity within an infecting bacterial population). Molecular differences at several different chromosomal loci identified among TPA strains or isolates have been used for molecular typing and the epidemiological characterization of syphilis isolates. This review summarizes genome structure of uncultivable pathogenic treponemes including genetically variable
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30303 - Infectious Diseases
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Infection, Genetics and Evolution
ISSN
1567-1348
e-ISSN
1567-7257
Volume of the periodical
61
Issue of the periodical within the volume
JUL 2018
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
16
Pages from-to
92-107
UT code for WoS article
000432516900014
EID of the result in the Scopus database
2-s2.0-85044597976