Macrolide resistance in yaws
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00102803" target="_blank" >RIV/00216224:14110/18:00102803 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/S0140-6736(18)30205-8" target="_blank" >http://dx.doi.org/10.1016/S0140-6736(18)30205-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0140-6736(18)30205-8" target="_blank" >10.1016/S0140-6736(18)30205-8</a>
Alternative languages
Result language
angličtina
Original language name
Macrolide resistance in yaws
Original language description
The study by Oriol Mitja and colleagues in The Lancet shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;2 it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G). Since its discovery, the A2059G mutation has been detected in T p pallidum isolates from patients with syphilis from Argentina,China, Czech Republic,the UK, Madagascar and the USA.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Lancet
ISSN
0140-6736
e-ISSN
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Volume of the periodical
391
Issue of the periodical within the volume
10130
Country of publishing house
US - UNITED STATES
Number of pages
2
Pages from-to
1555-1556
UT code for WoS article
000430542700006
EID of the result in the Scopus database
2-s2.0-85041680049