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Macrolide resistance in yaws

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00102803" target="_blank" >RIV/00216224:14110/18:00102803 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/S0140-6736(18)30205-8" target="_blank" >http://dx.doi.org/10.1016/S0140-6736(18)30205-8</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/S0140-6736(18)30205-8" target="_blank" >10.1016/S0140-6736(18)30205-8</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Macrolide resistance in yaws

  • Original language description

    The study by Oriol Mitja and colleagues in The Lancet shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;2 it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G). Since its discovery, the A2059G mutation has been detected in T p pallidum isolates from patients with syphilis from Argentina,China, Czech Republic,the UK, Madagascar and the USA.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Lancet

  • ISSN

    0140-6736

  • e-ISSN

  • Volume of the periodical

    391

  • Issue of the periodical within the volume

    10130

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    2

  • Pages from-to

    1555-1556

  • UT code for WoS article

    000430542700006

  • EID of the result in the Scopus database

    2-s2.0-85041680049