Wound heal­­ing ef­fects after application of polyunsaturated fatty acids in rat

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00104972" target="_blank" >RIV/00216224:14110/18:00104972 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.14735/amcsnn2018S29" target="_blank" >http://dx.doi.org/10.14735/amcsnn2018S29</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2018S29" target="_blank" >10.14735/amcsnn2018S29</a>

Result language

slovinština

Original language name

Wound healing effects after application of polyunsaturated fatty acids in rat

Original language description

Introduction: Although mechanisms of polyunsaturated fatty acids influence on skin wound heal- ing have not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. Aim: The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Materials and methods: Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3 : omega-6 : omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Results: Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Conclusion: Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

1802-4041

Volume of the periodical

81

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

„S29“-„S31“

UT code for WoS article

000452867800005

EID of the result in the Scopus database

2-s2.0-85093882666