Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00106959" target="_blank" >RIV/00216224:14110/18:00106959 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/18:00069475
Result on the web
<a href="http://dx.doi.org/10.1002/hon.2554" target="_blank" >http://dx.doi.org/10.1002/hon.2554</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hon.2554" target="_blank" >10.1002/hon.2554</a>
Alternative languages
Result language
angličtina
Original language name
Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies
Original language description
Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
<a href="/en/project/NV15-29508A" target="_blank" >NV15-29508A: Circulating nucleic acids as markers of multiple myeloma progression</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hematological Oncology
ISSN
0278-0232
e-ISSN
—
Volume of the periodical
36
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
786-791
UT code for WoS article
000452625700009
EID of the result in the Scopus database
2-s2.0-85053444771