ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY IS ONE OF THE ONTOLOGY GROUPS THAT ARE HIGHLY UP-REGULATED IN PORCINE OOCYTES BEFORE IN VITRO MATURATION

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00124603" target="_blank" >RIV/00216224:14110/18:00124603 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/18:00070307

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/30334402/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/30334402/</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

ENZYME LINKED RECEPTOR PROTEIN SIGNALING PATHWAY IS ONE OF THE ONTOLOGY GROUPS THAT ARE HIGHLY UP-REGULATED IN PORCINE OOCYTES BEFORE IN VITRO MATURATION

Original language description

Before being able to fully participate in the processes associated with its function as a female gamete, the oocyte needs to undergo a range of changes to achieve its mature form. These morphological, biochemical and metabolomic processes are induced by the somatic tissues surrounding the oocyte, through the expression of specific transcription and growth factors. The maturation of the oocyte is highly important for the proceedings that lead to successful fertilization, early embryonic development and implantation. Domestic pigs were used as models for our study, with the cumulus-oocyte complexes obtained from the ovaries that were recovered at slaughter. After shedding of the cumulus, oocytes were assessed with BCB test, with the viable ones chosen to undergo in vitro maturation. With the use of expression microarrays, we analyzed gene expression before and after IVM and detected major changes in both genes that were proven to be associated with oocyte maturation before (FOS, VEGFA, CHRDL1, TGFBR3, FST, INSR, ID1, TXNIP, SMAD4, MAP3K1, EIF2AK3 and KIT) and genes not previously linked with reproduction associated processes (MYO1E,PHII; KLF10 and SHOC2). All the genes were briefly described, with consideration of possible involvement of the newly discovered elements of the transcriptome in the process of oocyte maturation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of biological regulators and homeostatic agents

ISSN

0393-974X

e-ISSN

1724-6083

Volume of the periodical

32

Issue of the periodical within the volume

5

Country of publishing house

IT - ITALY

Number of pages

15

Pages from-to

1089-1103

UT code for WoS article

000449211700005

EID of the result in the Scopus database

2-s2.0-85055075805