Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00107357" target="_blank" >RIV/00216224:14110/19:00107357 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26220/19:PU133049
Result on the web
<a href="https://www.nature.com/articles/s41598-018-38199-7" target="_blank" >https://www.nature.com/articles/s41598-018-38199-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-018-38199-7" target="_blank" >10.1038/s41598-018-38199-7</a>

Result language
angličtina
Original language name
Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation
Original language description
We focused on the biomechanical and morphological characteristics of prostate cancer cells and their changes resulting from the effect of docetaxel, cisplatin, and long-term zinc supplementation. Cell population surviving the treatment was characterized as follows: cell stiffness was assessed by atomic force microscopy, cell motility and invasion capacity were determined by colony forming assay, wound healing assay, coherence-controlled holographic microscopy, and real-time cell analysis. Cells of metastatic origin exhibited lower height than cells derived from the primary tumour. Cell dry mass and CAV1 gene expression followed similar trends as cell stiffness. Docetaxel-and cisplatin-surviving cells had higher stiffness, and decreased motility and invasive potential as compared to non-treated cells. This effect was not observed in zinc(II)-treated cells. We presume that cell stiffness changes may represent an important overlooked effect of cisplatin-based anti-cancer drugs. Atomic force microscopy and confocal microscopy data images used in our study are available for download in the Zenodo repository.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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