Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108447" target="_blank" >RIV/00216224:14110/19:00108447 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jsbmb.2018.11.008" target="_blank" >http://dx.doi.org/10.1016/j.jsbmb.2018.11.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2018.11.008" target="_blank" >10.1016/j.jsbmb.2018.11.008</a>
Alternative languages
Result language
angličtina
Original language name
Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways
Original language description
In higher metazoans, the nuclear hormone receptors activate transcription trough their specific adaptors, nuclear hormone receptor adaptors NCoA, which are absent in lower metazoans. The Nine amino acid TransActivation Domain, 9aaTAD, was reported for a large number of the transcription activators that recruit general mediators of transcription. In this study, we demonstrated that the 9aaTAD from NHR-49 receptor of nematode C.elegans activates transcription as a small peptide. We showed that the ancient 9aaTAD domains are conserved in the nuclear hormone receptors including human HNF4, RARa, VDR and PPARg. Also their small 9aaTAD peptides effectively activated transcription in absence of the NCoA adaptors. We also showed that adjacent H11 domains in ancient and modern hormone receptors have an inhibitory effect on their 9aaTAD function.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV15-32935A" target="_blank" >NV15-32935A: Analysis of tumour-reactive gamma/delta T cells in patients with B-cell chronic lymphocytic leukaemia: a new approach to the cellular therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of steroid biochemistry and molecular biology
ISSN
0960-0760
e-ISSN
1879-1220
Volume of the periodical
187
Issue of the periodical within the volume
MAR 2019
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
118-123
UT code for WoS article
000459952100015
EID of the result in the Scopus database
2-s2.0-85057120463