Inappropriate conversion of current magnitude to current density may misinterpret results

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108532" target="_blank" >RIV/00216224:14110/19:00108532 - isvavai.cz</a>
Result on the web
<a href="https://esc365.escardio.org/Congress/EHRA-2019/Poster-session-2-43rd-EWGCCE-Meeting/190047-inappropriate-conversion-of-current-magnitude-to-current-density-may-misinterpret-results#abstract" target="_blank" >https://esc365.escardio.org/Congress/EHRA-2019/Poster-session-2-43rd-EWGCCE-Meeting/190047-inappropriate-conversion-of-current-magnitude-to-current-density-may-misinterpret-results#abstract</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Inappropriate conversion of current magnitude to current density may misinterpret results
Original language description
The magnitude of ionic current (I, in pA) is usually assumed to increase proportionally to the membrane area roughly estimated by measurement of the membrane capacitance (C, in pF). Hence, to lower differences of data measured in cells with varying cell membrane areas, the current density (J, in pA/pF) is routinely calculated as I/C ratio. However, if the I-C correlation was weak and insignificant, the conversion to J would be inappropriate and, if performed, could considerably change the interpretation of results.
Czech name
—
Czech description
—

Project
<a href="/en/project/NV16-30571A" target="_blank" >NV16-30571A: Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926C>T (p.T309I) as a possible long QT syndrome founder mutation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)