The role of cannabinoids in the treatment of cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00115321" target="_blank" >RIV/00216224:14110/20:00115321 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/20:00072651
Result on the web
<a href="http://dx.doi.org/10.4149/BLL_2020_012" target="_blank" >http://dx.doi.org/10.4149/BLL_2020_012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2020_012" target="_blank" >10.4149/BLL_2020_012</a>
Alternative languages
Result language
angličtina
Original language name
The role of cannabinoids in the treatment of cancer
Original language description
AIM: The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30223 - Anaesthesiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bratislava Medical Journal - Bratislavské lekárske listy
ISSN
0006-9248
e-ISSN
1336-0345
Volume of the periodical
121
Issue of the periodical within the volume
1
Country of publishing house
SK - SLOVAKIA
Number of pages
17
Pages from-to
79-95
UT code for WoS article
000507926100012
EID of the result in the Scopus database
2-s2.0-85077941355