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The role of cannabinoids in the treatment of cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00115321" target="_blank" >RIV/00216224:14110/20:00115321 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/20:00072651

  • Result on the web

    <a href="http://dx.doi.org/10.4149/BLL_2020_012" target="_blank" >http://dx.doi.org/10.4149/BLL_2020_012</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/BLL_2020_012" target="_blank" >10.4149/BLL_2020_012</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The role of cannabinoids in the treatment of cancer

  • Original language description

    AIM: The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30223 - Anaesthesiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Bratislava Medical Journal - Bratislavské lekárske listy

  • ISSN

    0006-9248

  • e-ISSN

    1336-0345

  • Volume of the periodical

    121

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    17

  • Pages from-to

    79-95

  • UT code for WoS article

    000507926100012

  • EID of the result in the Scopus database

    2-s2.0-85077941355