The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00116380" target="_blank" >RIV/00216224:14110/20:00116380 - isvavai.cz</a>

Result on the web

<a href="https://www.dovepress.com/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-co-peer-reviewed-article-CIA" target="_blank" >https://www.dovepress.com/the-effect-of-mindfulness-based-stress-reduction-mbsr-on-depression-co-peer-reviewed-article-CIA</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/CIA.S249196" target="_blank" >10.2147/CIA.S249196</a>

Result language

angličtina

Original language name

The Effect of Mindfulness-Based Stress Reduction (MBSR) on Depression, Cognition, and Immunity in Mild Cognitive Impairment : A Pilot Feasibility Study

Original language description

Background: Mindfulness-based programs have shown a promising effect on several health factors associated with increased risk of dementia and the conversion from mild cognitive impairment (MCI) to dementia such as depression, stress, cognitive decline, immune system and brain structural and functional changes. Studies on mindfulness in MCI subjects are sparse and frequently lack control intervention groups. Objective: To determine the feasibility and the effect of mindfulness-based stress reduction (MBSR) practice on depression, cognition and immunity in MCI compared to cognitive training. Methods: Twenty-eight MCI subjects were randomly assigned to two groups. MBSR group underwent 8-week MBSR program. Control group underwent 8-week cognitive training. Their cognitive and immunological profiles and level of depressive symptoms were examined at baseline, after each 8-week intervention (visit 2, V2) and six months after each intervention (visit 3, V3). MBSR participants completed feasibility questionnaire at V2. Results: Twenty MCI patients completed the study (MBSR group n=12, control group n=8). MBSR group showed significant reduction in depressive symptoms at both V2 (p=0.03) and V3 (p=0.0461) compared to the baseline. There was a minimal effect on cognition - a group comparison analysis showed better psychomotor speed in the MBSR group compared to the control group at V2 (p=0.0493) but not at V3. There was a detectable change in immunological profiles in both groups, more pronounced in the MBSR group. Participants checked only positive/neutral answers concerning the attractivity/length of MBSR intervention. More severe cognitive decline (PVLT=36) was associated with the lower adherence to home practice. Conclusion: MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile. Keywords

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30227 - Geriatrics and gerontology

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Interventions in Aging

ISSN

1176-9092

e-ISSN

1178-1998

Volume of the periodical

15

Issue of the periodical within the volume

August

Country of publishing house

NZ - NEW ZEALAND

Number of pages

17

Pages from-to

1365-1381

UT code for WoS article

000575553400001

EID of the result in the Scopus database

2-s2.0-85089485082