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Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120127" target="_blank" >RIV/00216224:14110/21:00120127 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.karger.com/Article/FullText/514286" target="_blank" >https://www.karger.com/Article/FullText/514286</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1159/000514286" target="_blank" >10.1159/000514286</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease

  • Original language description

    Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    <a href="/en/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetic score in prediction of diabetes and its complications</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    KIDNEY & BLOOD PRESSURE RESEARCH

  • ISSN

    1420-4096

  • e-ISSN

    1423-0143

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    10

  • Pages from-to

    152-161

  • UT code for WoS article

    000632543100001

  • EID of the result in the Scopus database

    2-s2.0-85103340484