Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120127" target="_blank" >RIV/00216224:14110/21:00120127 - isvavai.cz</a>
Result on the web
<a href="https://www.karger.com/Article/FullText/514286" target="_blank" >https://www.karger.com/Article/FullText/514286</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000514286" target="_blank" >10.1159/000514286</a>
Alternative languages
Result language
angličtina
Original language name
Pathophysiological Implication of Vitamin D in Diabetic Kidney Disease
Original language description
Background: Vitamin D is a hormone regulating not only calcium and phosphate homeostasis but also, at the same time, exerting many other extraskeletal functions via genomic effects (gene transcription) and probably by non-genomic effects as well. Availability is ensured by dietary intake of its precursors and by de novo production via sunlight. Yet, vitamin D deficiency and insufficiency are very common across the globe and are connected to many pathophysiological states, for example, diabetes mellitus, allergies, autoimmune diseases, pregnancy complications, and recently have also been associated with worse COVID-19 clinical outcomes. Summary: In this review, we summarize current knowledge about vitamin D metabolism in general, its role in diabetes mellitus (mainly type 2) and diabetic complications (mainly diabetic kidney disease), and potential therapeutic perspectives including vitamin D signalling as a druggable target. Key Messages: Vitamin D is not only a vitamin but also a hormone involved in many physiological processes. Its insufficiency or deficiency can lead to many pathological states.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
<a href="/en/project/NV18-01-00046" target="_blank" >NV18-01-00046: Genetic score in prediction of diabetes and its complications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
KIDNEY & BLOOD PRESSURE RESEARCH
ISSN
1420-4096
e-ISSN
1423-0143
Volume of the periodical
46
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
152-161
UT code for WoS article
000632543100001
EID of the result in the Scopus database
2-s2.0-85103340484