lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120232" target="_blank" >RIV/00216224:14110/21:00120232 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2218-273X/11/5/664" target="_blank" >https://www.mdpi.com/2218-273X/11/5/664</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/biom11050664" target="_blank" >10.3390/biom11050664</a>
Alternative languages
Result language
angličtina
Original language name
lncRNA PVT1 in the Pathogenesis and Clinical Management of Renal Cell Carcinoma
Original language description
LncRNA PVT1 (plasmacytoma variant translocation 1) has become a staple of the lncRNA profile in patients with renal cell carcinoma (RCC). Common dysregulation in renal tumors outlines the essential role of PVT1 in the development of RCC. There is already a plethora of publications trying to uncover the cellular mechanisms of PVT1-mediated regulation and its potential exploitation in management of RCC. In this review, we summarize the literature focused on PVT1 in RCC and aim to synthesize the current knowledge on its role in the cells of the kidney. Further, we provide an overview of the lncRNA profiling studies that have identified a more or less significant association of PVT1 with the clinical behavior of RCC. Based on our search, we analyzed the 17 scientific papers discussed in this review that provide robust support for the indispensable role of PVT1 in RCC development and future personalized therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/NV18-03-00554" target="_blank" >NV18-03-00554: Molecular classification of renal cell carcinoma based on long non-coding RNAs expression and its implication for diagnosis, prognosis and therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomolecules
ISSN
2218-273X
e-ISSN
2218-273X
Volume of the periodical
11
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1-12
UT code for WoS article
000653480900001
EID of the result in the Scopus database
2-s2.0-85105430023