Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F21%3A00120866" target="_blank" >RIV/00216224:14110/21:00120866 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1043661820316650?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.phrs.2020.105357" target="_blank" >10.1016/j.phrs.2020.105357</a>

Result language
angličtina
Original language name
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in perinatal delta9-tetrahydrocannabinol occurs in schizophrenia: analyses in patients and in animal model of the disease
Original language description
Reported data add further evidence to the dopamine-cannabinoid interaction in terms of DRD2 and CNR1 dysregulation which could be implicated in the pathogenesis of schizophrenia spectrum disorders, suggesting that cannabidiol treatment may normalize pTHC-induced psychopathology by modulating the altered dopaminergic activity.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Result description