Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00128073" target="_blank" >RIV/00216224:14110/22:00128073 - isvavai.cz</a>
Result on the web
<a href="https://haematologica.org/article/view/haematol.2020.265868" target="_blank" >https://haematologica.org/article/view/haematol.2020.265868</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2020.265868" target="_blank" >10.3324/haematol.2020.265868</a>
Alternative languages
Result language
angličtina
Original language name
Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria
Original language description
Paroxysmal nocturnal hemoglobinuria (PNH) is caused by clonal expansion of hematopoietic stem cells that carry a somatic mutation in the X-linked gene PIG-A (phosphatidylinositol glycan anchor biosynthesis class A). The mutation leads to a deficiency of glycosylphosphatidylinositol-anchored membrane proteins. The loss of membrane-associated complement regulatory proteins CD55 and CD59 increases susceptibility of red blood cells and platelets to complement-mediated lysis, leading to hemolytic anemia, thrombophilia and reduced life expectancy in untreated patients.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
—
Volume of the periodical
107
Issue of the periodical within the volume
6
Country of publishing house
IT - ITALY
Number of pages
6
Pages from-to
1483-1488
UT code for WoS article
000836816100029
EID of the result in the Scopus database
2-s2.0-85131218338