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Cryptic inhibitory regions nearby activation domains

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00129669" target="_blank" >RIV/00216224:14110/22:00129669 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/abs/pii/S030090842200116X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S030090842200116X?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.biochi.2022.05.004" target="_blank" >10.1016/j.biochi.2022.05.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Cryptic inhibitory regions nearby activation domains

  • Original language description

    Previously, the Nine amino acid TransActivation Domain (9aaTAD) was identified in the Gal4 region 862–870 (DDVYNYLFD). Here, we identified 9aaTADs in the distal Gal4 orthologs by our prediction algorithm and found their conservation in the family. The 9aaTAD function as strong activators was demonstrated. We identified adjacent Gal4 region 871–811 (DEDTPPNPKKE) as a natural 9aaTAD inhibitory domain located at the extreme Gal4 terminus. Moreover, we identified conserved Gal4 region 172–185 (FDWSEEDDMSDGLP), which was capable to reverse the 9aaTAD inhibition. In conclusion, our results uncover the existence of the cryptic inhibitory domains, which need to be carefully implemented in all functional studies with transcription factors to avoid incorrect conclusions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30105 - Physiology (including cytology)

Result continuities

  • Project

    <a href="/en/project/NV19-05-00410" target="_blank" >NV19-05-00410: Role of cytotoxic gamma-delta T cells implicated in therapeutic resistence and tumour recurrence in Glioblastoma Multiforme</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biochimie

  • ISSN

    0300-9084

  • e-ISSN

    1638-6183

  • Volume of the periodical

    200

  • Issue of the periodical within the volume

    September 2022

  • Country of publishing house

    FR - FRANCE

  • Number of pages

    8

  • Pages from-to

    19-26

  • UT code for WoS article

    000806357600003

  • EID of the result in the Scopus database

    2-s2.0-85130334483