Biology of Circular RNAs and Methodological Approaches to Their Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00132452" target="_blank" >RIV/00216224:14110/23:00132452 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/chapter/10.1007/978-3-031-36390-0_15" target="_blank" >https://link.springer.com/chapter/10.1007/978-3-031-36390-0_15</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-3-031-36390-0_15" target="_blank" >10.1007/978-3-031-36390-0_15</a>
Alternative languages
Result language
angličtina
Original language name
Biology of Circular RNAs and Methodological Approaches to Their Study
Original language description
Biology of Circular RNAs and Methodological Approaches to Their Study Michaela Ruckova, Dagmar Al Tukmachi & Ondrej Slaby Chapter First Online: 04 November 2023 232 Accesses Part of the RNA Technologies book series (RNATECHN,volume 14) Abstract From initially overlooked as peculiarities of uncertain biological importance or rare isoforms generated as a result of splicing errors to commonly regarded as relevant regulatory molecules, circular RNAs (circRNAs) now represent an extensively studied subgroup of non-coding RNAs (ncRNAs). The structural uniqueness of these endogenous biomolecules confers resistance to exonuclease activity, resulting in higher stability than observed in their linear counterparts, which alongside their reported function of gene expression regulators, predisposes them to potential use as robust biomarkers and/or powerful therapeutic targets. During the last decade, we have witnessed a boom in circRNA research deciphering various mechanisms of their biogenesis and an in-depth description of their biological functions, including miRNA and protein sponging, yet regulation of these events remains unclear. Despite recent advances in high-throughput genomic technology and novel bioinformatic approaches allowing circRNAs characterization in detail, analyzing these molecules continues to be challenging, leaving multiple biological knowledge gaps unsolved.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LX22NPO5102" target="_blank" >LX22NPO5102: National institute for cancer research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
RNA Structure and Function
ISBN
9783031363894
Number of pages of the result
16
Pages from-to
311-326
Number of pages of the book
666
Publisher name
Springer Cham
Place of publication
Switzerland
UT code for WoS chapter
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