Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish (Danio rerio)?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00133660" target="_blank" >RIV/00216224:14110/23:00133660 - isvavai.cz</a>
Result on the web
<a href="https://vetmed.agriculturejournals.cz/artkey/vet-202305-0005_long-term-exposure-to-polycyclic-musk-tonalide-8211-a-potential-threat-to-juvenile-zebrafish-danio-rerio.php" target="_blank" >https://vetmed.agriculturejournals.cz/artkey/vet-202305-0005_long-term-exposure-to-polycyclic-musk-tonalide-8211-a-potential-threat-to-juvenile-zebrafish-danio-rerio.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.17221/40/2023-VETMED" target="_blank" >10.17221/40/2023-VETMED</a>

Result language
angličtina
Original language name
Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish (Danio rerio)?
Original language description
Polycyclic musk compounds are commonly used in personal care products to replace expensive natural fragrances. Due to their huge consumption, they have become a part of the aquatic environment. In the present a two-month exposure effect of tonalide on juvenile zebrafish (Danio rerio) was investigated. We deter-mined the vitellogenin concentration to define the potential endocrine-disrupting effect of tonalide and also ana-selected indices to evaluate the induction of oxidative stress. The environmentally relevant concentration tonalide (i.e., 500 ng/l) caused a significant decrease in the catalase activity (P < 0.05) and a significant increase 0.05) in the lipid peroxidation. An increasing lipid peroxidation was also recorded for the highest concentra-group tested (i.e., 50 000 ng/l). On the other hand, no significant changes were recorded in vitellogenin in all exposed groups. Thus, based on these results, we have not demonstrated the endocrine-disrupting activity tonalide in zebrafish. The results of the oxidative stress indices showed a significant impairment of the anti-oxidant defence after the two-month tonalide exposure, which could indicate part of the adaptive response tonalide toxicity.
Czech name
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Czech description
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Type
Jimp - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40300 - Veterinary science

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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