Role of the 3-mercaptopyruvate sulfurtransferase in colon/ colorectal cancers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00136178" target="_blank" >RIV/00216224:14110/24:00136178 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0171933524000323?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0171933524000323?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejcb.2024.151415" target="_blank" >10.1016/j.ejcb.2024.151415</a>
Alternative languages
Result language
angličtina
Original language name
Role of the 3-mercaptopyruvate sulfurtransferase in colon/ colorectal cancers
Original language description
The 3-mercaptopyruvate sulfurtransferase (MPST) is a protein persulfidase, occurring mainly in mitochondria. Although function of this protein in cancer cells has been already studied, no clear outcome can be postulated up to now. Therefore, we focused on the determination of function of MPST in colon (HCT116 cells)/colorectal (DLD1 cells) cancers. In silico analysis revealed that in gastrointestinal cancers, MPST together with its binding partners can be either of a high risk or might have a protective effect. Silencing of MPST gene resulted in decreased ATP, while acetyl-CoA levels were elevated. Increased apoptosis was detected in cells with silenced MPST gene, which was accompanied by decrease in mitochondrial membrane potential, but no changes in IP3 receptor's protein. Mitochondria underwent activation of fission and elevated DRP1 expression after MPST silencing. Proliferation and migration of DLD1 and HCT116 cells were markedly affected, showing the importance of MPST protein in colon/colorectal cancer development.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Cell Biology
ISSN
0171-9335
e-ISSN
1618-1298
Volume of the periodical
103
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
1-12
UT code for WoS article
001230793100001
EID of the result in the Scopus database
2-s2.0-85190404964