Co-cultures of cerebral organoids with Glioblastoma cell line spheroids and Patient-derived tumoroids for investigating crosstalk with tumor microenvironment ex vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00137756" target="_blank" >RIV/00216224:14110/24:00137756 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Co-cultures of cerebral organoids with Glioblastoma cell line spheroids and Patient-derived tumoroids for investigating crosstalk with tumor microenvironment ex vivo
Original language description
Glioblastoma multiforme is the most aggressive type of brain tumor. The median survival time with GBM is 15 months and has not changed over the past 30 years. The reason is the high resistance of glioblastoma cells to currently used therapeutic procedures. It is, therefore, necessary to develop new therapeutic approaches for studying GBM biology. In particular, it is essential to develop preclinical in vitro models that better reflect the relationship between human brain tissue and the tumor. Such in vitro models can be used to study mechanisms of therapeutic resistance and screening of new drugs targeting GBM.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů