Impact of Post-Weaning Social Isolation on Left Ventricular Function in a Rat Model of Pressure-Volume Overload
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00138444" target="_blank" >RIV/00216224:14110/24:00138444 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Impact of Post-Weaning Social Isolation on Left Ventricular Function in a Rat Model of Pressure-Volume Overload
Original language description
The study investigates the effects of post-weaning social isolation (PWSI) on myocardial function in a rat model of pressure-volume overload. Sixteen male Sprague Dawley rats were divided into socially isolated and group-housed cohorts. Following 7 weeks of isolation, pressure-volume overload was induced using unilateral nephrectomy and deoxycorticosterone acetate (DOCA) treatment. Left ventricular function was assessed via pressure-volume catheterization. Socially isolated rats exhibited significantly reduced contractility and impaired relaxation compared to group-housed counterparts. The findings suggest that PWSI-induced behavioural alterations exacerbate cardiac dysfunction, highlighting a potential link between social stressors and cardiovascular health.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů