Pathophysiological Mechanisms and Pharmacological Interventions in Diabetic Nephropathy: Comparative Analysis in Diabetic Patients and Healthy Individuals.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00138578" target="_blank" >RIV/00216224:14110/24:00138578 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Pathophysiological Mechanisms and Pharmacological Interventions in Diabetic Nephropathy: Comparative Analysis in Diabetic Patients and Healthy Individuals.
Original language description
Diabetes mellitus, particularly type 2 diabetes, is a growing global health issue, with severe complications that affect multiple organ systems, including the kidneys. This thesis examines the intricate relationship between diabetes mellitus and renal function, focusing on the pathophysiological changes that occur in diabetic nephropathy. Diabetic nephropathy, one of the leading causes of end-stage renal disease, is characterized by glomerular hyperfiltration, damage to the filtration barrier, and mesangial matrix expansion, all of which lead to progressive renal dysfunction. The thesis explores the underlying mechanisms of these renal alterations, highlighting the role of chronic hyperglycemia, oxidative stress, and the formation of advanced glycation endproducts (AGEs) in promoting kidney damage. In particular, it details how these factors contribute to glomerular sclerosis and impair renal filtration, ultimately resulting in chronic kidney failure.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5104" target="_blank" >LX22NPO5104: National Institute for Research of Metabolic and Cardiovascular Diseases</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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