Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00139931" target="_blank" >RIV/00216224:14110/24:00139931 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/s41386-023-01763-5" target="_blank" >https://www.nature.com/articles/s41386-023-01763-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41386-023-01763-5" target="_blank" >10.1038/s41386-023-01763-5</a>

Result language

angličtina

Original language name

Examining the association between posttraumatic stress disorder and disruptions in cortical networks identified using data-driven methods

Original language description

Posttraumatic stress disorder (PTSD) is associated with lower cortical thickness (CT) in prefrontal, cingulate, and insular cortices in diverse trauma-affected samples. However, some studies have failed to detect differences between PTSD patients and healthy controls or reported that PTSD is associated with greater CT. Using data-driven dimensionality reduction, we sought to conduct a well-powered study to identify vulnerable networks without regard to neuroanatomic boundaries. Moreover, this approach enabled us to avoid the excessive burden of multiple comparison correction that plagues vertex-wise methods. We derived structural covariance networks (SCNs) by applying non-negative matrix factorization (NMF) to CT data from 961 PTSD patients and 1124 trauma-exposed controls without PTSD. We used regression analyses to investigate associations between CT within SCNs and PTSD diagnosis (with and without accounting for the potential confounding effect of trauma type) and symptom severity in the full sample. We performed additional regression analyses in subsets of the data to examine associations between SCNs and comorbid depression, childhood trauma severity, and alcohol abuse. NMF identified 20 unbiased SCNs, which aligned closely with functionally defined brain networks. PTSD diagnosis was most strongly associated with diminished CT in SCNs that encompassed the bilateral superior frontal cortex, motor cortex, insular cortex, orbitofrontal cortex, medial occipital cortex, anterior cingulate cortex, and posterior cingulate cortex. CT in these networks was significantly negatively correlated with PTSD symptom severity. Collectively, these findings suggest that PTSD diagnosis is associated with widespread reductions in CT, particularly within prefrontal regulatory regions and broader emotion and sensory processing cortical regions.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

<a href="/en/project/NV18-04-00559" target="_blank" >NV18-04-00559: Neurobiological and psychological markers of reaction to extreme stress and its impact on offspring - three generation study of holocaust survivors and their offspring</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuropsychopharmacology

ISSN

0893-133X

e-ISSN

1740-634X

Volume of the periodical

49

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

609-619

UT code for WoS article

001123265200001

EID of the result in the Scopus database

2-s2.0-85177736426