Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00141617" target="_blank" >RIV/00216224:14110/25:00141617 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0166432825003298" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0166432825003298</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbr.2025.115742" target="_blank" >10.1016/j.bbr.2025.115742</a>
Alternative languages
Result language
angličtina
Original language name
Repeated administration of AMPA/kainate antagonists transiently suppresses nicotine-seeking in an operant rat model
Original language description
This study evaluated the impact of repeated intravenous administration of AMPA/kainate receptor antagonists, NBQX and CNQX, on the operant nicotine self-administration in rats. Wistar rats were subjected to operant intravenous self-administration of nicotine under a fixed ratio 1 schedule of reinforcement. During the maintenance phase of self-administration, 5 mg/kg intravenous NBQX was administered daily prior to the session for a duration of 10 days. Subsequently, the rats underwent a forced abstinence period, remaining in their home cages for two weeks. Following the abstinence, a reinstatement session was conducted. During the final 3 days of abstinence and preceding the reinstatement session, the animals were treated with either NBQX or CNQX (5 and 6 mg/kg intravenously, respectively) to assess their effect on drug-seeking behavior. A ten-day treatment with NBQX did not have any significant influence on the nicotine intake. Repeated administration of NBQX or CNQX before reinstatement had no effect on nicotine-seeking behavior in terms of total numbers of operant responses. However, both of these ligands decreased the number of active nose-pokes (nicotine-seeking) in the first 20 min of the reinstatement session. While no effect of repeated NBQX treatment on nicotine intake was observed, this study reports a transient effect of repeated NBQX or CNQX treatment in the reinstatement of nicotine-seeking behavior in an operant IVSA model. Further pharmacokinetic studies may help optimize behavioral protocols assessing the potential role of AMPA/kainate antagonists in the field of nicotine addiction research where current evidence remains limited.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BEHAVIOURAL BRAIN RESEARCH
ISSN
0166-4328
e-ISSN
1872-7549
Volume of the periodical
494
Issue of the periodical within the volume
October 2025
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
8
Pages from-to
1-8
UT code for WoS article
001548873100001
EID of the result in the Scopus database
2-s2.0-105010894010