Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00142756" target="_blank" >RIV/00216224:14110/25:00142756 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Neurodegeneration in Mesial Temporal Lobe Epilepsy (MTLE) Absence of Alpha-Synuclein and TDP-43 Pathology
Original language description
The growing body of evidence concerning the presence of pathological aggregates of hyperphosphorylated tau protein and beta-amyloid in resection specimens from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) is well-documented. Recent studies have also suggested alterations in serum levels of alpha-synuclein in this population1,2. Another protein associated with neurodegeneration, TAR DNA-binding protein 43 (TDP-43), has not yet been extensively studied in epilepsy patients. Given this background, the present study aims to investigate the presence of alphasynuclein and TDP-43 pathological aggregates in tissue samples from patients with MTLE sourced from two comprehensive tertiary epilepsy centers
Czech name
—
Czech description
—
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů