Fibroblast Growth Factors in Lung Development and Regeneration: Mechanisms and Therapeutic Potential
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00143806" target="_blank" >RIV/00216224:14110/25:00143806 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2073-4409/14/16/1256" target="_blank" >https://www.mdpi.com/2073-4409/14/16/1256</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells14161256" target="_blank" >10.3390/cells14161256</a>
Alternative languages
Result language
angličtina
Original language name
Fibroblast Growth Factors in Lung Development and Regeneration: Mechanisms and Therapeutic Potential
Original language description
Fibroblast growth factors (FGFs) play a key role in lung development by mediating complex interactions between epithelial and mesenchymal cells, which are central to processes such as branching morphogenesis, epithelial differentiation, and alveolarization. The findings regarding this interplay highlight the complexity of FGF signaling, as different FGFs contribute to various aspects of lung formation and maturation. Understanding the role of FGF proteins in shaping the lung is crucial for gaining insight into the biology of its development. Furthermore, FGFs orchestrate complex signaling pathways that regulate lung regeneration in adulthood. Therapeutic strategies targeting FGF-dependent pathways appear promising for repairing and improving lung function in diverse pulmonary diseases. In this review, we describe the current perception of the role of FGF proteins in lung development and regeneration, together with an overview of emerging therapeutic strategies aiming at FGF signaling in lung-related disorders.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
14
Issue of the periodical within the volume
16
Country of publishing house
CH - SWITZERLAND
Number of pages
25
Pages from-to
1-25
UT code for WoS article
001557342900001
EID of the result in the Scopus database
2-s2.0-105014453926