Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00144445" target="_blank" >RIV/00216224:14110/25:00144445 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Smart regrowth of mouse incisor: Impacts of incisor damage on growth and morphology

Original language description

Mechanosensation and mechanotransduction are critical processes in various biological systems, underpinning development, regeneration, and tissue repair. Mice possess continuously growing incisors that renew throughout their lifespan, offering an exceptional model for studying tissue homeostasis and regeneration. Despite the known importance of stem cell activity in the dental pulp for incisor renewal, the mechanisms controlling this process, particularly in response to mechanical stimuli or injury, remain unclear. In this study, we aimed to elucidate how mechanical stimuli or injury influence normal incisor growth using a tooth-clipping injury model. Furthermore, we examined whether clipping injury triggers phenotypical changes and alters the mechanical properties of the tooth and the surrounding alveolar bone. Finally, at the cellular level, we analyzed signaling adaptations in tooth-forming cells and elucidated changes in cell proliferation dynamics within the stem cell niche. Our findings reveal that incisor shortening induces complex phenotypical changes, influencing both cellular behavior and molecular signaling. The insights from this study shed light on how mechanical cues modulate structural and functional dynamics of incisor regeneration, providing a deeper understanding of the role of mechanosensing in tooth renewal and adaptation.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GA25-18087S" target="_blank" >GA25-18087S: Cellular Basis of Dental Healing</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů