Natural compounds with dual antimicrobial and anti-inflammatory effects
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F20%3A00118254" target="_blank" >RIV/00216224:14160/20:00118254 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s11101-020-09694-5" target="_blank" >https://link.springer.com/article/10.1007/s11101-020-09694-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11101-020-09694-5" target="_blank" >10.1007/s11101-020-09694-5</a>
Alternative languages
Result language
angličtina
Original language name
Natural compounds with dual antimicrobial and anti-inflammatory effects
Original language description
Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory activity. The review contains also the information about structure-activity relationships with respect to natural or semisynthetic origin of compounds and synergy effects between natural dual inhibitors and commercially available antibiotics. Data published from 2000 to 2018 were obtained using databases Google Scholar, Science Direct and Web of Science, and searching keywords such asalkaloids,anti-inflammatory activity, antimicrobial activity, chalcones, coumarins, flavonoids, IC50, lignans, MIC, natural compounds,synergistic effectandterpenoids, alone or in a combination. The primary criteria for the selection of appropriate compounds were the MICs and IC(50)s used for a quantification of effects. The natural compounds with activity close to the reference substances or showing MIC up to 32 mu g ml(-1), and IC(50)of anti-inflammatory effect up to 15 mu M were considered as promising. When available, information about in vivo testing was included. Reviewed dual inhibitors can represent modern therapeutic approach, especially when the process of inflammation is followed by a secondary bacterial infection. Benefits of dual inhibitors are based on better compliance of patients, decreased number of side effects and extended spectrum of action. [GRAPHICS] .
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Phytochemistry reviews
ISSN
1568-7767
e-ISSN
1572-980X
Volume of the periodical
19
Issue of the periodical within the volume
6
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
32
Pages from-to
1471-1502
UT code for WoS article
000543051200001
EID of the result in the Scopus database
2-s2.0-85086863550