Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00123234" target="_blank" >RIV/00216224:14160/21:00123234 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Design, synthesis and antiproliferative activity of newly designed derivatives of N-hydroxycinnamide
Original language description
Histone acetylation is a process controlled by histone deacetylases (HDAC) and histone acetyltransferases (HAT), and it plays an essential role in the regulation of gene expression. HDACs are a family of enzymes that modulate the acetylation status of histones and non-histone proteins. Inhibitors of HDAC (HDACi), which form a complex with Zn2+ ion in the enzyme active site, are novel antiproliferative agents that induce tumor cell death, differentiation, and/or cell cycle arrest.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů