Parenteral depot dosage forms in psychiatry and the development of a new particulate dosage form of mirtazapine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126273" target="_blank" >RIV/00216224:14160/22:00126273 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/afpuc-2022-0008" target="_blank" >http://dx.doi.org/10.2478/afpuc-2022-0008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/afpuc-2022-0008" target="_blank" >10.2478/afpuc-2022-0008</a>
Alternative languages
Result language
čeština
Original language name
Parenteral depot dosage forms in psychiatry and the development of a new particulate dosage form of mirtazapine
Original language description
The main advantages of depot psychotropic drugs include improved adherence to treatment, absence of problems with absorption from the gastrointestinal tract, circumvention of first-pass metabolism and absence of risk of accidental or intentional overdose. The development of depot dosage forms is currently focused on the study of microparticles. The drug content, morphology and dissolution test were evaluated for the prepared microparticles containing mirtazapine. The pharmacokinetic profile of administered microparticles was determined based on frequent sampling. The serum was further used to determine liver tests, the lipid spectrum and selected adipokines.
Czech name
Parenteral depot dosage forms in psychiatry and the development of a new particulate dosage form of mirtazapine
Czech description
The main advantages of depot psychotropic drugs include improved adherence to treatment, absence of problems with absorption from the gastrointestinal tract, circumvention of first-pass metabolism and absence of risk of accidental or intentional overdose. The development of depot dosage forms is currently focused on the study of microparticles. The drug content, morphology and dissolution test were evaluated for the prepared microparticles containing mirtazapine. The pharmacokinetic profile of administered microparticles was determined based on frequent sampling. The serum was further used to determine liver tests, the lipid spectrum and selected adipokines.
Classification
Type
O - Miscellaneous
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
—
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů