Preparation and evaluation of spray-dried microparticles containing colistin or liposomes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126882" target="_blank" >RIV/00216224:14160/22:00126882 - isvavai.cz</a>
Result on the web
<a href="https://www.pharm.muni.cz/veda-a-vyzkum/svk/doktorsti-studenti/archiv-sborniku/2022" target="_blank" >https://www.pharm.muni.cz/veda-a-vyzkum/svk/doktorsti-studenti/archiv-sborniku/2022</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Preparation and evaluation of spray-dried microparticles containing colistin or liposomes
Original language description
In this study, a formulation containing the antibacterial agent colistin for lung application was prepared using different input spray drying parameters (temperature, dispersion or ingredient concentration, nozzle size). In the second part, the incorporation of liposomes (as a potential carrier for colistin) into the microparticles and their stability after the drying process were evaluated. The results show the best properties with a high leucine concentration, dilution of input dispersion, and high drying temperature. Compositions used for liposome batches were not completely effective in stabilizing vesicles during spray drying. However, increasing the concentration of mannitol protectant shows promising results, and the findings obtained are of great importance for further optimization.
Czech name
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Czech description
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Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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