Evaluation of the stability of biologically active chlorinated arylcarbamoylnaphthalenylcarbamates by RP-HPLC

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00129754" target="_blank" >RIV/00216224:14160/22:00129754 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Evaluation of the stability of biologically active chlorinated arylcarbamoylnaphthalenylcarbamates by RP-HPLC
Original language description
The original carbamates with excellent antimicrobial activity derived from 1-hydroxy-N-(2,4,5-trichlorophenyl)-2-naphthamide were investigated for their stability. 2-[N-(2,4,5-Trichlorophenyl)- carbamoyl]naphthalen-1-yl ethyl carbamate with the weakest steric protection, i.e., with the expected highest degradability and two other carbamates with a more sterically protected carbamate bond (2-[N-(2,4,5-trichlorophenyl)carbamoyl]naphthalen-1-yl 2-phenylethyl carbamate and 2-[N-(2,4,5-trichlorophenyl)carbamoyl]- naphthalen-1-yl isopropyl carbamate), i.e., with the expected lower degradability, were chosen. The developed HPLC methods using chromatographic columns with phenyl-based stationary phases and acetonitrile:phosphate buffer (pH = 2.5) as the mobile phases provided sufficient resolution between the studied carbamates and expected degradant, pattern anilide.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Proceedings of the 18th International Students Conference “Modern Analytical Chemistry”
ISBN
9788074440939
ISSN
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e-ISSN
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Number of pages
78
Pages from-to
1-6
Publisher name
Charles University, Faculty of Science
Place of publication
Praha
Event location
Praha
Event date
Sep 15, 2022
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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