SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00132384" target="_blank" >RIV/00216224:14160/23:00132384 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/afpuc-2023-0022" target="_blank" >http://dx.doi.org/10.2478/afpuc-2023-0022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/afpuc-2023-0022" target="_blank" >10.2478/afpuc-2023-0022</a>
Alternative languages
Result language
angličtina
Original language name
SCHIFF BASES AS POTENTIAL THERAPEUTIC AND ANTICANCER AGENTS
Original language description
Basic thiosemicarbazone and semicarbazone derivatives of acetophenone with imine functional group belong to the group commonly called Schiff bases. Therapeutics and compounds belonging to this group are versatile pharmacophores with a significant capability of forming chelates with various metal ions. Such metal complexes play an important role in therapeutics due to their remarkable broad-spectrum of biological activities. Due to the above-mentioned complex formation, many Schiff bases appear as an important intermediate in a number of enzymatic reactions. One of the possible target enzyme is a neutral zinc-binding metalloenzyme aminopeptidase N (AP-N), also called membrane alanyl aminopeptidase. Potential inhibitors of this omnipresent enzyme may offer effective and broad-spectrum therapy. Through three-step synthesis it is possible to obtain three arene substitution isomers of basic thiosemicarbazone and semicarbazone derivatives of acetophenone.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
<a href="/en/project/EF19_073%2F0016943" target="_blank" >EF19_073/0016943: Internal grant agency of Masaryk University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů