Anti-inflammatory and antioxidant activity of dibenzocyclooctadiene lignans from Schisandra chinensis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F24%3A00139767" target="_blank" >RIV/00216224:14160/24:00139767 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Anti-inflammatory and antioxidant activity of dibenzocyclooctadiene lignans from Schisandra chinensis

Original language description

Some dibenzocyclooctadiene lignans have shown antioxidant activity.The highest antioxidant activity was demonstrated by (-)-gomisin J (p &lt; 0.001). This activity corresponded to approximately 50% of the activity of quercetin (p&lt; 0.001), which served as a positive control. The anti-inflammatory activity was detected for (−)-gomisin N (p&lt; 0.0001) and (+)-γ-schisandrin (p&lt; 0.0001)at a concentration of 10 μM. The activity of these compounds was higher than that of the positive control prednisolone (p&lt; 0.0001) at a concentration 2 μM.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

<a href="/en/project/GA23-04655S" target="_blank" >GA23-04655S: Role of prenylation and glycosylation patterns in anti-inflammatory activity and metabolism of natural phenolic compounds</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů