Geranylated Flavonoids from Paulownia tomentosa Suppress Cancer Cell Proliferation and Trigger Apoptosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00141800" target="_blank" >RIV/00216224:14160/25:00141800 - isvavai.cz</a>
Result on the web
<a href="https://fd2025.sk/assets_congress/fd2025_sk2025/docs/72-nd-czech-slovak-pharmacological-days_1.pdf" target="_blank" >https://fd2025.sk/assets_congress/fd2025_sk2025/docs/72-nd-czech-slovak-pharmacological-days_1.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Geranylated Flavonoids from Paulownia tomentosa Suppress Cancer Cell Proliferation and Trigger Apoptosis
Original language description
The presence of secondary metabolites in Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae), particularly geranylated flavonoids, has recently garnered significant attention in the search for new biologically active compounds. Although these naturally occurring substances are found in a limited number of plant families, they are noteworthy for their potential pharmacological properties. Recently, geranylated flavonoids have been extensively studied for their various biological activities, which include anti-inflammatory, antibacterial, antioxidant, and cytotoxic effects. In this study, we showed that geranylated flavonoids from Paulownia tomentosa can effectively inhibit the growth of cancer cells, particularly the DU-145 prostate cancer cell line. The tested substances further induce apoptosis and changes in the mitochondrial activity of cancer cells.
Czech name
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Czech description
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Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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