Undescribed prenylated anthraquinones from Asperula sintenisii Asch. Ex Bornm. with cytotoxic activities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00142527" target="_blank" >RIV/00216224:14160/25:00142527 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0367326X2500471X?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0367326X2500471X?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2025.106845" target="_blank" >10.1016/j.fitote.2025.106845</a>
Alternative languages
Result language
angličtina
Original language name
Undescribed prenylated anthraquinones from Asperula sintenisii Asch. Ex Bornm. with cytotoxic activities
Original language description
Two previously unreported anthraquinones, named sintenisiquinones A (1) and B (2), were isolated from the MeOH extract of Asperula sintenisii together with five iridoid glycosides, five flavonoids, as well as three phenolic acid derivatives. Their chemical structures were elucidated on the basis of extensive 1D (1H and 13C) and 2D (COSY, HSQC, and HMBC) NMR spectroscopy and HRESIMS. Compounds 1 and 2 represent rare type of anthraquinone derivatives bearing a prenyl group cyclized to dihydrofuran ring. The in vitro cytotoxic activities of selected compounds (1-3, 5, 7, 11, 12 and 15) were evaluated against SW480, DU145, MCF7, and A549 cancer cell lines as well as a healthy cell line, L929 by MTS assay. Compounds 1 and 2 displayed weak cytotoxicity compared to positive control, doxorubicin. This is the first phytochemical and bioactivity studies on A. sintenisii, an endemic species to T & uuml;rkiye.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fitoterapia
ISSN
0367-326X
e-ISSN
1873-6971
Volume of the periodical
186
Issue of the periodical within the volume
neuvedeno
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
1-7
UT code for WoS article
001595290500002
EID of the result in the Scopus database
2-s2.0-105013873518