Spray-dried solid inhalable N-acetylcysteine microparticles: Preparation and mucolytic activity testing

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00142980" target="_blank" >RIV/00216224:14160/25:00142980 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1016/j.jddst.2025.107622" target="_blank" >https://doi.org/10.1016/j.jddst.2025.107622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2025.107622" target="_blank" >10.1016/j.jddst.2025.107622</a>

Result language

angličtina

Original language name

Spray-dried solid inhalable N-acetylcysteine microparticles: Preparation and mucolytic activity testing

Original language description

Inhalation is the preferred administration for treating pulmonary disorders like cystic fibrosis, with the use of mucolytics such as N-acetylcysteine being the main therapeutic strategy. This study aimed to develop spray-dried inhalable microparticles, using N-acetylcysteine and mannitol as a carrier and osmotic agent. Various methodologies were assessed to optimize the spray drying process, including different drying conditions and additives in the dispersion. The results demonstrated the requirements for particular excipients to formulate N-acetylcysteine–mannitol inhalable microparticles by spray drying. Incorporating a neutralizing agent (sodium hydroxide) or glass transition temperature modifiers (dextran, maltodextrin, chitosan) produced spherical primary particles that readily agglomerated into large clusters. Leucine, as an antiadherent agent, demonstrated efficacy as the sole excipient at a concentration of 20–25 %, facilitating the formulation of particles with appropriate size, shape, and morphology. Inhalable particles (mass median aerodynamic diameter 5.95 ± 1.53 μm, fine particle fraction 33.06 %) were prepared by modifying process parameters (nozzle size reduction, feed solution dilution). The encapsulated N-acetylcysteine also showed sustained mucolytic activity in vitro (35.3 % viscosity reduction after 120 min), using an innovative method. This work represents the complex study of N-acetylcysteine inhalable microparticles preparation as a possible approach to overcome liquid formulation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

ISSN

1773-2247

e-ISSN

2588-8943

Volume of the periodical

114

Issue of the periodical within the volume

B

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

14

Pages from-to

1-14

UT code for WoS article

001594167000001

EID of the result in the Scopus database

2-s2.0-105018769263