Electrochemical Detection of Interactions of Echinomycin with DNA at Mercury Film Electrodes (MFE).

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F01%3A00007523" target="_blank" >RIV/00216224:14310/01:00007523 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical Detection of Interactions of Echinomycin with DNA at Mercury Film Electrodes (MFE).
Original language description
The dependence of the impedance Z and/or differential capacitance C of the electrode double layer on electrode potential E and on frequency in solutions of echinomycin with single stranded (ss) and double-helical (double stranded, ds) DNA was measured. Echinomycin gives a pseudocapacitance redox peak on the C-E curves at the potential of -0.53 V. This peak is observed with the dsDNA-echinomycin comlex as well, but not with ssDNA treated by echinomycin. The capacitance measurements can thus distinguish with the aid of bis-intercalator echinomycin the ss and ds form of DNA adsorbed at the electrode surface. This promise to use impedance measurements for detection of dsDNA in hybridization reactins.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Book of Abstracts, US-CZ Workshops on Electrochemical Sensors Prague 2001
ISBN
80-86238-15-6
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
42
Publisher name
US-CZ Workshop on Electrochemical Sensors Prague
Place of publication
Prague
Event location
Prague 19-22.6.2001
Event date
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Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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