Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F02%3A00006911" target="_blank" >RIV/00216224:14310/02:00006911 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Roscovitine-stabilized p53 suppresses growth and induces differentiation of v-myb-transformed monoblasts

Original language description

BM2 monoblasts constitutively express v-myb oncogene and their terminal differentiation steps are blocked. However, using phorbol esters the terminal differentiation can be resumed. We wished to explore the role of p53 in regulation of differentiation, proliferation and apoptosis of BM2 cells. We inducibly expressed human p53 in chicken BM2 cells. Upon stabilization using roscovitine the p53 protein was capable to suppress growth and induce terminal differentiation of BM2 cells.

Czech name

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Czech description

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Type

D - Article in proceedings

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2002

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection

Cells IV

ISBN

80-7232-181-1

ISSN

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e-ISSN

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Number of pages

1

Pages from-to

95

Publisher name

Kopp Publishing

Place of publication

České Budějovice

Event location

9.-11.9 2002, České Budějovice

Event date

Jan 1, 2002

Type of event by nationality

CST - Celostátní akce

UT code for WoS article

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