Trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines: Chiral recognition and Transformations

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F02%3A00007021" target="_blank" >RIV/00216224:14310/02:00007021 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Trans-4-(4-fluorophenyl)-3-substituted-1-methylpiperidines: Chiral recognition and Transformations
Original language description
The title compounds 2 (Z = OH, Cl, Br, OCH3, mesyl, tosyl, 3,4-(methylenedioxy)phenoxy) are synthetic precursors of an antidepressive drug paroxetine 1 [1]. Chiral recognition of 2 was observed by NMR spectroscopy in the presence of (S)-Mosher acid 5. For most substrates in the series, the non-equivalence induced in their 1H and 19F NMR spectra was sufficiently large to allow the evaluation of enantiomeric purity [2].
Czech name
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Czech description
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Project
<a href="/en/project/OC%20D10.20" target="_blank" >OC D10.20: Chemical transformations iniciated by microwaves</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Book of Abstracts from the 14th International Symposium on Chirality
ISBN
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ISSN
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e-ISSN
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Number of pages
1
Pages from-to
91
Publisher name
Hamburg University
Place of publication
Hamburg, Německo
Event location
8.-12.9.2002; Hamburg, Německo
Event date
Jan 1, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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