(R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010157" target="_blank" >RIV/00216224:14310/04:00010157 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/04:00000041
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
(R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinium chloride propan-1-ol solvate
Original language description
The title compound, C21H24FN2O2+.Cl-.C3H8O, is a potential drug designed as a hybrid compound with antihypertensive, antioxidant and -adrenolytic activity. The cation contains nearly planar benzofuran and fluorophenyl ring systems, as well as a piperazine ring adopting an almost perfect chair conformation. The benzofuran and piperazine moieties are connected by an ethyl chain, the moieties forming a dihedral angle of 163.12 (13)deg. In the crystal structure, ions and propanol solvent molecules are linked via N-HCl and O-HCl bonds into linear (010) chains.
Czech name
Chlorid (R)-4-(4-Fluorophenyl)-1-[2-hydroxy-2-(3-methyl-1-benzofuran-2-yl)ethyl]piperazinia solvatovaný propan-1-olem
Czech description
V práci ji diskutována RTG struktura titulní sloučeniny - potenciálního léčiva s antihypertensivními, antioxidantními a beta-adrenolytickými aktivitami.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GA203%2F02%2F0436" target="_blank" >GA203/02/0436: Application of Crystallographic Databases in Scientific Practice</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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