Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00035994" target="_blank" >RIV/00216224:14310/04:00035994 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel Imidazopyrazines as Cyclin Dependent Kinase Inhibitors

Original language description

In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compds. I [R = CF3, (un)substituted-alkyl, -heteroaryl, -heteroarylalkyl, -cycloalkyl, -heterocyclyl, etc.; R1 = H, halo or alkyl; R2 = H, halo, CN, cycloalkyl, heterocyclyl, alkynyl and CF3; R3 = aryl (with exception of Ph), (un)subsituted-heteroaryl (with exception of furyl), -heterocyclyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one ormore such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by substitution of 8-chloro-6-methylimidzol[1,2-a]pyrazine with 3-(aminomethyl)pyridine. Methods for performing assays with I are described (no data).

Czech name

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Czech description

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Type

P - Patent

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2004

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Patent/design ID

WO 2004/026310 A1.

Publisher

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Publisher name

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Place of publication

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Publication country

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Date of acceptance

Apr 1, 2004

Owner name

Schering-Plough

Method of use

A - Výsledek využívá pouze poskytovatel

Usage type

A - K využití výsledku jiným subjektem je vždy nutné nabytí licence