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Functional analysis of p53 tumor suppressor in yeast

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00013878" target="_blank" >RIV/00216224:14310/05:00013878 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Functional analysis of p53 tumor suppressor in yeast

  • Original language description

    The p53 tumor suppressor protein is a transcription factor that mediates the cells response to various kinds of stress by preventing cell division and/or inducing apoptosis. p53 gene mutations have been detected in nearly 50% of human cancers. Several approaches have been developed for detection and analyses of p53 mutations: immunochemical methods have been developed to detect p53 protein levels; molecular analyses targeting changes in DNA structure are utilized; and functional assays are used to explore the biological properties of the p53 protein. Functional analysis of separated alleles in yeast targets the transactivation capability of the p53 protein expressed in yeast cells. This method uses p53 mRNA isolated from cells and tissues to produce p53 product by RT-PCR. This method serves as a powerful tool for distinguishing various functional types of p53 mutations.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Differentiation

  • ISSN

    0301-4681

  • e-ISSN

  • Volume of the periodical

    73

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    17

  • Pages from-to

  • UT code for WoS article

  • EID of the result in the Scopus database