Polymorphism of DRD2 gene and ADHD

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00016583" target="_blank" >RIV/00216224:14310/06:00016583 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Polymorphism of DRD2 gene and ADHD

Original language description

Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p &lt; 0,008, p &lt; 0,002, respectively) of DRD2 polymorphism between two studied groups of boys.

Czech name

Polymorphism of DRD2 gene and ADHD

Czech description

Objectives: Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood disorder. Evidence from the family and twin studies suggest that ADHD is familiar and highly heritable. Association studies are frequently used for the searching of markers responsible for genetic basis of ADHD. We investigated TaqI polymorphism of the dopamine receptor D2 (DRD2) in relationship with ADHD. The association between TaqI A polymorphism of DRD2 gene and ADHD has previously been published. Design: We used the association study to test the relationship between TaqI A polymorphism of DRD2 gene and ADHD on groups of ADHD boys and control boys. Setting: For DNA isolation, buccal tissue was used. PCR with restriction analysis of PCR products was used for genotyping. Results: We found statistically different genotypic and allelic frequencies (p &lt; 0,008, p &lt; 0,002, respectively) of DRD2 polymorphism between two studied groups of boys.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FL - Psychiatry, sexology

OECD FORD branch

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Project

<a href="/en/project/NF6520" target="_blank" >NF6520: Clinical and molecular-biological correlates of attention deficit hyperactivity disorder in children</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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