Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00018449" target="_blank" >RIV/00216224:14310/06:00018449 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio)

Original language description

OBJECTIVES: Xenoestrogenic potential of propylparaben (PP), one of the most commonly used preservatives in drugs, cosmetics and food, was investigated in vivo using zebrafish (Danio rerio). METHODS: Juvenile zebrafish (20 days post hatching) were exposedto three different concentrations of propylparaben (PP) dissolved in ethanol and added into the water. After 20 days of exposure the fish were euthanized and vitellogenin concentrations in their whole body homogenates were measured by the method of direct sandwich ELISA. Simultaneously, vitellogenin concentrations in either fish from the control group (exposed to solvent without the substance tested) and in fish from the positive control group (exposed to natural estrogen 17B-estradiol) were measured.RESULTS: Vitellogenin concentration in whole body homogenates of control fish was 400 (396?540) ng.ml?1 (geometric mean (95% CI)). Zebrafish exposure to propylparaben at the concentrations of 0.1; 0.4 and 0.9 mg.l?1 elicited statistically

Czech name

Evaluation of xenoestrogenic potential of propylparaben in zebrafish (Danio rerio)

Czech description

OBJECTIVES: Xenoestrogenic potential of propylparaben (PP), one of the most commonly used preservatives in drugs, cosmetics and food, was investigated in vivo using zebrafish (Danio rerio). METHODS: Juvenile zebrafish (20 days post hatching) were exposedto three different concentrations of propylparaben (PP) dissolved in ethanol and added into the water. After 20 days of exposure the fish were euthanized and vitellogenin concentrations in their whole body homogenates were measured by the method of direct sandwich ELISA. Simultaneously, vitellogenin concentrations in either fish from the control group (exposed to solvent without the substance tested) and in fish from the positive control group (exposed to natural estrogen 17B-estradiol) were measured.RESULTS: Vitellogenin concentration in whole body homogenates of control fish was 400 (396?540) ng.ml?1 (geometric mean (95% CI)). Zebrafish exposure to propylparaben at the concentrations of 0.1; 0.4 and 0.9 mg.l?1 elicited statistically

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

DJ - Pollution and water control

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172?780X

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

Suppl.2

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

101-107

UT code for WoS article

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EID of the result in the Scopus database

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