Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00019133" target="_blank" >RIV/00216224:14310/07:00019133 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines
Original language description
Nestin (intermediate filament class VI protein) is expressed in proliferating neuroepithelium during the development of mammalian CNS as well as in human and rodent neural stem cells and cell lines. In the adult CNS, nestin is detectable only in stem cells of the subventricular zone and partly in the choroid plexus. Our study was aimed at the nestin expression in cell lines derived from different types of solid tumors both in children and adults. Using immunodetection methods, nestin expression has beenshown in tissue sections and cell lines derived from neuroectodermal tumors (glioblastoma multiforme, neuroblastoma), as well as from malignant fibrose histiocytoma and osteosarcoma. We also focused on the subcellular localization of nestin in the celllines as described above. Our results brought the direct evidence of the nestin occurrence in cell nucleus in cell lines derived from neuroblastoma and glioblastoma multiforme.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9125" target="_blank" >NR9125: Importance of molecular cytogenetic markers for diagnosis and prediction of embryonal childhood tumors.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů