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Review: Application of capillary electrophoresis in drug metabolism studies

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00020296" target="_blank" >RIV/00216224:14310/07:00020296 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Review: Application of capillary electrophoresis in drug metabolism studies

  • Original language description

    Capillary electrophoresis (CE) has been increasingly employed for the separation of pharmaceutical agents and drugs. This has arisen from the complementary mode of separation afforded by CE when compared to high performance liquid chromatography (HPLC).Qualities of CE such as high efficiency of separation, short analysis time, remarkably low injection volume and a variety of detection systems have facilitated acceptance of this technology. Since different drug metabolite enantiomers are formed in manymetabolic pathways, the other indispensable advantage of CE over HPLC is the possibility of chiral separation without the need of special expensive columns. Recent advances in automated systems have made CE even more popular. The focus of this paper is to review recent studies and advances (mainly from 2000) of drug metabolism by using CE. The review is divided into two parts: (i) principles of CE separation of drugs and their metabolites and (ii) application of CE in drug metabolism stu

  • Czech name

    Review: Využití kilární elektroforézy pro studium metabolismu léčiv

  • Czech description

    Tento přehledný článek shrnuje problematiku využití CE pro studium metabolismu léčiv.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Analytical Chemistry

  • ISSN

    1573-4110

  • e-ISSN

  • Volume of the periodical

    3

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    21

  • Pages from-to

    197-217

  • UT code for WoS article

  • EID of the result in the Scopus database